03. Chronic blistering cutaneous conditions

Mucous Membrane Pemphigoid

Understanding Mucous Membrane Pemphigoid: A Comprehensive Overview What is Mucous Membrane Pemphigoid? Mucous membrane pemphigoid (MMP), also known as cicatricial pemphigoid, is a rare chronic autoimmune disorder characterized by the formation of blistering lesions on mucous membranes and, in some cases, the skin. This condition falls under the category of pemphigoid diseases, which are known… read more »

Pemphigus vulgaris

Pemphigus vulgaris Micrograph of pemphigus vulgaris with the characteristic “tombstoning”. H&E stain. Specialty Dermatology  Pemphigus vulgaris Pemphigus vulgaris is a rare chronic blistering skin disease and the most common form of pemphigus. Pemphigus was derived from the Greek word pemphix, meaning blister.[1] It is classified as a type II hypersensitivity reaction in which antibodies are formed against desmosomes, components of the skin that function to keep… read more »

Cicatricial pemphigoid

Mucous membrane pemphigoid Other names Cicatricial pemphigoid; MMP, Benign mucosal pemphigoid, Benign mucous membrane pemphigoid,[1] Ocular pemphigoid,[2] and Scarring pemphigoid[1]) Specialty Dermatology  Mucous membrane pemphigoid is a rare chronic autoimmune subepithelial blistering disease characterized by erosive lesions of the mucous membranes and skin.[3] It is one of the pemphigoid diseases that can result in scarring.[4] Signs and symptoms The autoimmune reaction most commonly affects the oral mucosa in the mouth, causing lesions… read more »

Bullous lupus erythematosus

Lupus erythematosus Specialty Rheumatology Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues.[1] Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs. The most common and most severe form is systemic lupus erythematosus. Signs and symptoms Symptoms vary from person to person, and may come and go. Almost everyone… read more »

Bullous pemphigoid

Bullous pemphigoid A photo of legs covered in popped blisters caused by bullous pemphigoid. The blisters cover his entire body. Specialty Dermatology  Bullous pemphigoid is an autoimmune pruritic skin disease preferentially in older people, aged over 60, that may involve the formation of blisters (bullae) in the space between the epidermal and dermal skin layers. The disorder is a type of pemphigoid. It is classified as a type II hypersensitivity reaction,… read more »

Linear IgA disease

Linear IgA bullous dermatosis (a) Widespread vesiculobullous eruption on the lower limbs with elements in a “string of pearls” arrangement; (b) targetoid vesicular lesions on erythematous skin involving the dorsa of the hands; (c) blisters with a “string of pearls” configuration and crusts in the perioral area; (d) erythematous, vesicular lesions partially eroded on the… read more »

Grover’s disease

Transient acantholytic dermatosis Grover’s disease Micrograph of transient acantholytic dermatosis, showing subcorneal separation and acantholysis.H&E stain. Grover’s disease (GD), also known as benign papular acantholytic dermatosis,[1] transient acantholytic dermatosis,[1] and persistent acantholytic dermatosis[1] is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis[2]:529 with or without dyskeratosis.[3] Once confirmed, most cases of Grover’s disease last… read more »

Dermatitis herpetiformis

Dermatitis herpetiformis (DH), or Duhring’s disease,[1][2] is a chronic blistering skin condition,[3] characterised by blisters filled with a watery fluid.[4]Despite its name, DH is neither related to nor caused by herpes virus: the name means that it is a skin inflammation having an appearance similar to herpes. DH was first described by Louis Adolphus Duhring… read more »

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